Fluorescence diagnosis and photodynamic therapy in intra-abdominal gynecologic diseases and breast cancer – A review
Author(s): Martin Löning, Philipp Soergela and Peter Hillemanns
Fluorescence diagnosis (FD) and photodynamic therapy (PDT) with 5-aminolevulinic acid (5-ALA)-induced protoporpyrin IX are promising
new options in the diagnosis and therapy of diseases in a wide spectrum of medical disciplines such as urology, dermatology, gastroenterology and neurosurgery.
FD is based on the application of the heme precursor 5-ALA which induces the endogenous accumulation of the photosensitizer protoporphyrin IX (PpIX) in designated
tissues. After excitation with blue light, a strong red fluorescence can be initiated particularly in tumorous tissues. PDT involves the use of photochemical
reactions mediated through the interaction of photosensitizing agents, light and oxygen for the treatment of malignant or benign diseases.