Fluorescence Detection of Pleural Malignancies Using 5-Aminolaevulinic Acid
Author(s): Paul Baas, MD, FCCP; Martijn Triesscheijn, MSc; Sjaak Burgers, MD, PhD; Renee van Pel, MD, PhD; Fiona Stewart, PhD; and Maurice Aalders, PhD
Although the use of video-assisted thoracoscopy has improved the diagnostic accuracy in patients presenting with
pleural diseases, not all biopsies performed are conclusive and staging of the disease is not always optimal. Fluorescence diagnosis (FD) with
5-aminolaevulinic acid (5-ALA) has been used in the diagnostic workup for various malignancies. The impact of 5-ALA-mediated FD on diagnosis and
staging during video-assisted thoracoscopy was examined.
In-vivo kinetics of inhaled 5-Aminolevulinic acid-Induced Protoporphyrin IX fluorescence in bronchial tissue
Author(s): Hubert Hautmann, Josef P Pichler, Herbert Stepp, Reinhold Baumgartner, Fernando Gamarra and Rudolf M Huber
In the diagnosis of early-stage lung cancer photosensitizer-enhanced fluorescence bronchoscopy with inhaled 5-aminolevolinic acid (5-ALA)
increases sensitivity when compared to white-light bronchoscopy. This investigation was to evaluate the in vivo tissue pharmacokinetics of inhaled 5-ALA within the
bronchial mucosa in order to define the time optimum for its application prior to bronchoscopy.